What is sermorelin?
Sermorelin is a synthetic version of the first 29 amino acids of growth hormone-releasing hormone (GHRH), the hypothalamic peptide that signals the pituitary gland. Because that short fragment keeps the receptor-binding part of the full hormone, it is often written as GRF 1-29 or GHRH (1-29). Supplier labels usually say sermorelin or sermorelin acetate, the salt form of the peptide, and that labeled amount is what the sermorelin dosage calculator on this page starts from.
It belongs to the GHRH-analog family, alongside longer-acting relatives such as CJC-1295. It is a different class from growth hormone secretagogues like ipamorelin, which act on a separate receptor. This page does not describe any use in people. It handles one job: the sermorelin dosage calculator math of reconstituting a vial with bacteriostatic water and reading the result on a U-100 syringe.
How much BAC water for a sermorelin vial?
Research vials are commonly labeled 2 mg, 5 mg, 9 mg or 10 mg of freeze-dried powder. The milligrams in the vial never change; the water you add decides the concentration. The chart below shows micrograms per unit on a U-100 syringe for several water volumes.
| BAC water | 2 mg vial | 5 mg vial | 9 mg vial | 10 mg vial |
|---|---|---|---|---|
| 1 mL | 20 mcg/unit 2 mg/mL | 50 mcg/unit 5 mg/mL | 90 mcg/unit 9 mg/mL | 100 mcg/unit 10 mg/mL |
| 2 mL | 10 mcg/unit 1 mg/mL | 25 mcg/unit 2.5 mg/mL | 45 mcg/unit 4.5 mg/mL | 50 mcg/unit 5 mg/mL |
| 3 mL | 6.67 mcg/unit 0.667 mg/mL | 16.67 mcg/unit 1.667 mg/mL | 30 mcg/unit 3 mg/mL | 33.33 mcg/unit 3.333 mg/mL |
| 5 mL | 4 mcg/unit 0.4 mg/mL | 10 mcg/unit 1 mg/mL | 18 mcg/unit 1.8 mg/mL | 20 mcg/unit 2 mg/mL |
Each cell shows mcg per unit on a U-100 syringe (100 units = 1 mL) and the resulting concentration.
Read across a row to compare vial sizes at the same water volume, or down a column to see how extra water spreads the same powder thinner. More water always means fewer micrograms in each unit. The 9 mg size is less common and gives less round numbers, which is exactly where a chart helps. If you want the same logic for every vial size on one page, see the BAC water to peptide ratio chart.
Worked example: sermorelin reconstitution in syringe units
The calculator runs three steps. Vial mg ÷ water mL gives the concentration. The amount you enter ÷ that concentration gives the volume in mL. Volume in mL × 100 gives U-100 units. For example, if the amount you already have is 100 mcg, and the vial is 2 mg with 2 mL of water added:
The math: 2 mg ÷ 2 mL = 1 mg/mL (1,000 mcg/mL), which is 10 mcg per unit. 100 mcg ÷ 1,000 mcg/mL = 0.1 mL = 10 units on a U-100 syringe.
The same math applies to a sermorelin 5mg reconstitution. For example, if the amount you already have is 250 mcg and the 5 mg vial holds 2.5 mL of water:
The math: 5 mg ÷ 2.5 mL = 2 mg/mL (2,000 mcg/mL), which is 20 mcg per unit. 250 mcg ÷ 2,000 mcg/mL = 0.125 mL = 12.5 units on a U-100 syringe.
Both amounts are arbitrary figures picked because they come out clean, not suggestions. The most common error is a unit mix-up: 1 mg = 1,000 mcg, so an answer that is off by a factor of 1,000 almost always means mg and mcg were swapped. The mg to mcg conversion guide covers that step.
Sermorelin dosage calculator: dosage chart and units explained
People looking for a sermorelin dosage chart, sermorelin dosing information or sermorelin dosage in units usually want to know which syringe mark matches an amount. That is the question this page answers. You bring the amount; the sermorelin dosage calculator converts it into mL and units based on your vial size and the water you actually added. It does not set, suggest or check a dose, a schedule or a frequency. Those come from product labeling and a qualified professional, not from a calculator.
The chart above is a units chart, not a dosing chart: every cell shows how many micrograms sit in one unit for that vial and water combination. Units are the same size on every U-100 syringe, where 100 units = 1 mL and 1 unit = 0.01 mL. A 0.3 mL or 0.5 mL syringe simply holds fewer units, so the count from the calculator reads the same on each. The U-100 syringe units to mL guide has a full conversion table.
Sermorelin 2mg and 5mg mixing instructions: what suppliers say
Searches for sermorelin 5mg mixing instructions or sermorelin 2mg mixing instructions usually come down to two numbers: the vial size and the water volume. The math for any combination is in the chart and calculator above. The physical handling is set by the product, not by this page.
- Some suppliers specify bacteriostatic water as the diluent; others ship sermorelin with their own diluent, so the label on your product takes priority.
- Some labels describe letting the water run down the inside wall of the vial and swirling gently rather than shaking, since vigorous agitation can foam a peptide solution.
- Storage before and after mixing, and how long a mixed vial is kept, vary by product and should be read from its labeling.
The same rules apply to larger vials such as sermorelin 9mg or a sermorelin 10mg dosage question: only the concentration changes. For general handling background, the peptide reconstitution guide walks through the full process in general terms.
Sermorelin regulatory status
Sermorelin acetate was once an FDA-approved drug sold as Geref. It was later discontinued by its manufacturer, so there is no current Geref product on the market. Vials sold online today are labeled for research use and are not that approved product; their identity, purity and sterility cannot be confirmed by a calculator.
The numbers on this page are arithmetic only. They assume the vial contains exactly what the label states and that you know how much water went in. To compare sermorelin with other calculators, browse the peptide library.
Sermorelin FAQ
Is this a sermorelin dosage calculator?
It converts an amount you already have into mL and U-100 syringe units for your vial size and water volume. It does not recommend or check a dose, schedule or frequency.
How much BAC water goes in a sermorelin 5 mg vial?
There is no single correct volume. More water gives fewer micrograms per unit and less water gives more. The chart shows mcg per unit for several volumes, and the product labeling controls what is used.
Does the calculator work for 9 mg or 10 mg sermorelin vials?
Yes. Enter the milligrams printed on the vial and the water you added. The same formula works for 2, 5, 9 and 10 mg vials.
Is sermorelin the same as GRF 1-29?
Yes. Sermorelin is the first 29 amino acids of growth hormone-releasing hormone, which is why it is also written as GRF 1-29 or GHRH (1-29).
Is sermorelin FDA-approved?
Sermorelin acetate was once FDA-approved as Geref, which was later discontinued by its manufacturer. Research-labeled vials are not that approved product.