What is gonadorelin?
Gonadorelin reconstitution is mostly a question of arithmetic: how much BAC water goes into the vial and what that does to each syringe unit. Before the math, the compound itself. Gonadorelin is a synthetic peptide with the same ten-amino-acid sequence as natural gonadotropin-releasing hormone, usually shortened to GnRH and also called luteinizing hormone-releasing hormone (LHRH). Its sequence is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.
Gonadorelin is different from the long list of modified GnRH analogues, which change one or more amino acids in that chain. Gonadorelin keeps the natural sequence. Salts such as gonadorelin acetate may appear on labels; the calculator only needs the mg of peptide printed on the vial. This page makes no statement about what gonadorelin does in the body.
How much BAC water for a gonadorelin vial?
Research vials are most often labeled gonadorelin 2mg or gonadorelin 10mg of freeze-dried powder. The mg in the vial is fixed; the volume of bacteriostatic water you add sets the concentration. The chart shows micrograms per unit on a U-100 syringe at common water volumes.
| BAC water | 2 mg vial | 10 mg vial |
|---|---|---|
| 1 mL | 20 mcg/unit 2 mg/mL | 100 mcg/unit 10 mg/mL |
| 2 mL | 10 mcg/unit 1 mg/mL | 50 mcg/unit 5 mg/mL |
| 3 mL | 6.67 mcg/unit 0.667 mg/mL | 33.33 mcg/unit 3.333 mg/mL |
| 5 mL | 4 mcg/unit 0.4 mg/mL | 20 mcg/unit 2 mg/mL |
Each cell shows mcg per unit on a U-100 syringe (100 units = 1 mL) and the resulting concentration.
Read across a row to compare the two vial sizes at the same volume, or down a column to see how more water spreads the same powder thinner. The two sizes are far apart, so a 10 mg vial carries five times as much peptide per unit as a 2 mg vial at the same water volume. There is no single correct volume. For the ratio behind these numbers, see the BAC water to peptide ratio guide.
Worked example: gonadorelin 2mg reconstitution
The calculator runs three steps. Vial mg ÷ water mL gives the concentration. The amount you enter ÷ that concentration gives the volume in mL. Volume × 100 gives U-100 units. For example, if the amount you already have is 100 mcg, and a gonadorelin 2mg vial is mixed with 2 mL of BAC water:
The math: 2 mg ÷ 2 mL = 1 mg/mL (1,000 mcg/mL), which is 10 mcg per unit. 100 mcg ÷ 1,000 mcg/mL = 0.1 mL = 10 units on a U-100 syringe.
That amount is an arbitrary figure picked because it comes out clean. It is not a suggestion. With a gonadorelin 10mg vial and the same water, the concentration is five times higher, so the same amount takes one fifth of the units:
The math: 10 mg ÷ 2 mL = 5 mg/mL (5,000 mcg/mL), which is 50 mcg per unit. 100 mcg ÷ 5,000 mcg/mL = 0.02 mL = 2 units on a U-100 syringe.
Keep everything in one unit before dividing: 1 mg = 1,000 mcg. The mg to mcg conversion guide covers that step.
Gonadorelin dosage: what the calculator does and doesn’t do
Many people who search for gonadorelin dosage are really asking how many units on the syringe match a number they already have. The calculator above answers exactly that. It takes the mg on the label, the mL of water you added and the amount you enter, and returns a concentration, a volume and a unit mark.
It does not choose an amount, a schedule or a frequency, and it cannot tell you whether a product is suitable or genuine. That belongs to the product labeling and a qualified professional. Units are the same size on every U-100 syringe: 100 units = 1 mL and 1 unit = 0.01 mL. A 0.3 mL syringe holds 30 of them, a 0.5 mL syringe 50. If a result looks wrong, you can check the calculator math by hand.
Gonadorelin reconstitution notes from suppliers
Supplier instructions vary, so the label on your vial comes first. Some suppliers specify bacteriostatic water as the diluent; others list sterile water. Because a 2 mg vial holds a small amount of powder, some product sheets point out that the cake can look very thin or appear to be missing, and that this is normal for a small freeze-dried fill. Some suppliers say to swirl gently rather than shake, and many give a separate storage temperature for the mixed solution.
A 10 mg vial is sometimes mixed with a larger volume simply to keep unit counts easy to read. That changes only the concentration. Whatever volume you use, enter that exact figure in the calculator so the result matches what is in the vial. General mixing steps are in the peptide reconstitution guide.
Gonadorelin regulatory status
Gonadorelin has an FDA history: gonadorelin products (Factrel and Lutrepulse) were approved in the past, but they have since been discontinued, and no approved gonadorelin product for people is currently marketed in the US. The vials sold online today are labeled for research use and are not an approved medicine. They carry no approved strength, directions or quality standard to compare against. The only numbers you can rely on are the mg printed on the vial and the water volume you measured.
Gonadorelin is also often mentioned next to kisspeptin-10 and hCG, since all relate to the same hormonal axis; they are separate compounds with separate calculators. A correct calculation cannot confirm identity, purity, sterility or stability. Treat any result as arithmetic, not as a statement that a product is safe or suitable for any use.
Gonadorelin FAQ
How much BAC water do you add to a gonadorelin 2mg vial?
There is no single required volume. The chart shows how 1, 2, 3 and 5 mL change the mcg per unit. Follow the product labeling for the diluent and volume, then enter the volume you used.
Does this page give a gonadorelin dosage?
No. It converts an amount you already have into mL and U-100 syringe units for your vial and water volume. It does not recommend a dose, schedule or frequency.
Is gonadorelin the same as GnRH?
Gonadorelin is a synthetic peptide with the same ten-amino-acid sequence as natural gonadotropin-releasing hormone, which is why it is often called synthetic GnRH.
Why does a gonadorelin 10mg vial give fewer units for the same amount?
With the same water volume, five times the powder gives five times the concentration, so the same amount fits in one fifth of the volume and one fifth of the units.
Can I use the calculator for gonadorelin acetate?
Yes. Enter the mg printed on the vial label as the vial size and the BAC water volume you added. The math is the same whatever salt form the label lists.