What is the Semax peptide?
Semax is a synthetic peptide developed in Russia from a short piece of adrenocorticotropic hormone (ACTH), a hormone made by the pituitary gland. It takes the ACTH(4-7) fragment, Met-Glu-His-Phe, and adds a Pro-Gly-Pro tail for stability, giving the seven-residue sequence Met-Glu-His-Phe-Pro-Gly-Pro. Supplier labels say Semax or Semax acetate, and every Semax reconstitution on this page starts from that labeled powder.
Semax is not the same compound as Selank. They share the Pro-Gly-Pro ending and a Russian research origin, but Semax is derived from a hormone fragment, while Selank is derived from tuftsin, an immune-protein fragment. Research interest in Semax has focused on its activity as a regulatory neuropeptide in laboratory work; this page makes no claims about effects in people. What it does cover is Semax reconstitution: the math of mixing a vial with bacteriostatic water.
How much BAC water for a Semax vial?
Semax research vials are sold in a wider range than many peptides, commonly 5 mg, 10 mg and 30 mg of freeze-dried powder. The powder amount is fixed; the water you add sets the concentration. The chart shows micrograms per unit on a U-100 syringe.
| BAC water | 5 mg vial | 10 mg vial | 30 mg vial |
|---|---|---|---|
| 1 mL | 50 mcg/unit 5 mg/mL | 100 mcg/unit 10 mg/mL | 300 mcg/unit 30 mg/mL |
| 2 mL | 25 mcg/unit 2.5 mg/mL | 50 mcg/unit 5 mg/mL | 150 mcg/unit 15 mg/mL |
| 3 mL | 16.67 mcg/unit 1.667 mg/mL | 33.33 mcg/unit 3.333 mg/mL | 100 mcg/unit 10 mg/mL |
| 5 mL | 10 mcg/unit 1 mg/mL | 20 mcg/unit 2 mg/mL | 60 mcg/unit 6 mg/mL |
Each cell shows mcg per unit on a U-100 syringe (100 units = 1 mL) and the resulting concentration.
Read across a row to compare vial sizes at the same water volume, and down a column to see how more water lowers the micrograms in each unit. Notice how much higher the 30 mg column sits than a semax 5mg vial: at the same water volume, the larger vial puts far more powder into every unit. That makes unit counts very small for small amounts, which is one reason people choose larger water volumes for big vials. For the general logic, see the BAC water to peptide ratio chart.
Worked example: Semax 10mg reconstitution and 30 mg math
The calculator works in three steps. Vial mg ÷ water mL gives the concentration. The amount you enter ÷ that concentration gives the volume in mL. Volume in mL × 100 gives U-100 units. For example, if the amount you already have is 500 mcg, and the vial is 10 mg with 2 mL of water added:
The math: 10 mg ÷ 2 mL = 5 mg/mL (5,000 mcg/mL), which is 50 mcg per unit. 500 mcg ÷ 5,000 mcg/mL = 0.1 mL = 10 units on a U-100 syringe.
The same steps apply to a large vial. For example, if the amount you already have is 1 mg and a 30 mg vial holds 3 mL of water:
The math: 30 mg ÷ 3 mL = 10 mg/mL (10,000 mcg/mL), which is 100 mcg per unit. 1 mg ÷ 10,000 mcg/mL = 0.1 mL = 10 units on a U-100 syringe.
Both amounts are arbitrary and picked because they come out clean; neither is a suggestion. Note the second example uses mg while the first uses mcg. Since 1 mg = 1,000 mcg, entering the wrong unit gives an answer off by a factor of 1,000. The mg to mcg conversion guide covers the switch.
Semax reconstitution notes from suppliers
Semax reconstitution follows the general pattern for freeze-dried peptides, but the product label decides the details.
- Some suppliers specify bacteriostatic water as the diluent for their vials; others note a different solvent, so read your product’s label first.
- Some labels describe running the water down the inside wall of the vial and swirling gently rather than shaking, to avoid foaming.
- Storage before and after mixing, and how long a mixed vial is kept, vary by product and come from its labeling.
The calculator only needs two numbers from you: the milligrams printed on the vial and the water volume you added. If you want the process described in general terms, the peptide reconstitution guide walks through it.
Semax spray and Semax Selank blend questions
Semax spray is a frequent search. This calculator measures liquid in U-100 syringe units. Nasal sprays are measured by the volume each pump delivers, which depends on the device, so this page does not convert amounts into sprays or give spray instructions.
Some suppliers also sell a semax selank blend in one vial. A blend contains two compounds in a fixed ratio, so each unit of liquid holds some of both. The calculator works one component at a time: enter that component’s milligrams as the vial size, and the result applies to that component only. For the Selank side on its own, use the Selank reconstitution calculator.
Semax regulatory status
Semax is not FDA-approved. Vials sold online are labeled for research use, and a calculator cannot confirm their identity, purity or sterility. The math assumes the vial holds exactly what the label states and that you know the water volume you added. For other research compounds, browse the peptide library.
Semax FAQ
How much BAC water for a Semax 10 mg vial?
There is no single correct volume. More water gives fewer micrograms per unit and less water gives more. The chart shows mcg per unit for several volumes, and the product labeling controls what is used.
Does this calculator work for a Semax 30 mg vial?
Yes. Enter 30 as the vial size and the water you added. Larger vials give more micrograms per unit, so small amounts take fewer units.
Can I use this for Semax spray?
No. The calculator works in U-100 syringe units. Nasal sprays are measured by the volume each pump delivers, which depends on the device.
How do I use the calculator for a Semax Selank blend?
Work one component at a time. Enter the milligrams of the component you are calculating as the vial size; the result applies to that component only.
Is Semax the same as Selank?
No. Both are seven-amino-acid peptides ending in Pro-Gly-Pro, but Semax comes from a fragment of the hormone ACTH and Selank comes from tuftsin, an immune-protein fragment.
Is Semax FDA-approved?
No. Semax is not FDA-approved, and research-labeled vials are sold for research use only.