What is ARA-290 (cibinetide)?
ARA-290 is an investigational peptide with the nonproprietary name cibinetide. It is a short linear peptide modeled on the helix B region of erythropoietin (EPO), which is why the research literature also calls it pyroglutamate helix B surface peptide (pHBSP). It was designed to be studied separately from EPO’s effects on red blood cell production, and it has been evaluated in clinical research without reaching FDA approval.
The name ARA-290 is a development code, and cibinetide is its international nonproprietary name; both refer to the same peptide. Vials may carry either name, so matching a label to this page means checking for one or the other, along with the mg amount.
Research vials of ARA-290 are sold as a freeze-dried powder, usually in 10 mg and 16 mg sizes. This page covers ARA-290 reconstitution math only: how much liquid goes into the vial, what concentration that creates, and how an amount you already have converts into units on a U-100 syringe.
How much BAC water for an ARA-290 vial?
There is no single correct volume. The liquid you add sets the concentration: less liquid puts more micrograms into each syringe unit, and more liquid spreads the same amount across more units so it is easier to read. The chart shows micrograms per U-100 unit for both common ARA-290 vial sizes at several volumes.
| BAC water | 10 mg vial | 16 mg vial |
|---|---|---|
| 2 mL | 50 mcg/unit 5 mg/mL | 80 mcg/unit 8 mg/mL |
| 3 mL | 33.33 mcg/unit 3.333 mg/mL | 53.33 mcg/unit 5.333 mg/mL |
| 4 mL | 25 mcg/unit 2.5 mg/mL | 40 mcg/unit 4 mg/mL |
| 5 mL | 20 mcg/unit 2 mg/mL | 32 mcg/unit 3.2 mg/mL |
Each cell shows mcg per unit on a U-100 syringe (100 units = 1 mL) and the resulting concentration.
The 16 mg column is not a round multiple of the 10 mg column, so the two sizes rarely line up at the same volume. Always enter the exact mg printed on your label. The BAC water to peptide ratio guide explains the underlying ratio.
Supplier instructions for ARA-290 sometimes name a volume along with the liquid. If yours does, the matching row in the chart shows the micrograms per unit that volume produces; for any volume not shown, enter it in the calculator instead.
ARA-290 16 mg reconstitution: worked example
Every result uses three steps: vial mg ÷ liquid mL = mg per mL; amount ÷ concentration = mL; and mL × 100 = U-100 units. For a 16 mg vial, for example, if the amount you already have is 0.6 mg:
The math: 16 mg ÷ 4 mL = 4 mg/mL (4,000 mcg/mL), which is 40 mcg per unit. 0.6 mg ÷ 4,000 mcg/mL = 0.15 mL = 15 units on a U-100 syringe.
For a 10 mg vial, for example, if the amount you already have is the same 0.6 mg:
The math: 10 mg ÷ 4 mL = 2.5 mg/mL (2,500 mcg/mL), which is 25 mcg per unit. 0.6 mg ÷ 2,500 mcg/mL = 0.24 mL = 24 units on a U-100 syringe.
With the same liquid volume, the smaller vial makes a weaker solution, so the same amount takes more units. Units are the same size on every U-100 syringe; the U-100 syringe units to mL chart shows the full scale.
ARA-290 dose calculator: what the numbers mean
Searches for an ARA-290 dose usually come from someone who already has an amount and wants to know how it translates into liquid and syringe units. That conversion is what the calculator here provides. You enter the vial size, the liquid volume, and your amount, and it returns concentration, mL, and units.
The chart is a unit-conversion table, not a dosing table. No row is a recommendation, and nothing on this page sets an ARA-290 dose, schedule, or route. Those belong to the product labeling and a qualified professional. To confirm a result by hand, use the peptide calculator math check.
ARA-290 peptide reconstitution with PBS or BAC water
ARA-290 is one of the compounds where supplier instructions vary on the liquid itself:
- PBS. Some suppliers specify reconstitution in phosphate-buffered saline (PBS) rather than bacteriostatic water.
- BAC water. Other suppliers list bacteriostatic water. Whichever liquid the label names takes priority over any general guide.
- The math does not change. Concentration depends only on the mg in the vial and the mL of liquid added, so the chart and calculator apply to PBS, BAC water, or any other labeled diluent.
- Storage. Some suppliers specify refrigeration after mixing. A punctured multi-dose vial follows its own label and the common 28-day guidance for opened multi-dose vials.
For how saline-based solutions compare with BAC water, see BAC water vs saline for peptides.
Is ARA-290 FDA-approved?
No. ARA-290 (cibinetide) is investigational and is not an FDA-approved drug. Research-labeled vials sold online are not approved medicines, and their identity, purity, and sterility depend entirely on the supplier. A correct calculation cannot confirm any of those things.
Because it has been through clinical research, ARA-290 has more published literature than many research peptides. That history does not make a research-labeled vial equivalent to trial material, and it says nothing about how any particular vial was made or stored.
ARA-290 FAQ
What is ARA-290?
ARA-290, also called cibinetide, is an investigational peptide modeled on the helix B region of erythropoietin. It is not FDA-approved and is sold for research as a freeze-dried powder.
Can ARA-290 be reconstituted with PBS?
Some suppliers specify phosphate-buffered saline for ARA-290, while others list bacteriostatic water. Follow the product label. The calculator math is the same for either, because only the liquid volume affects concentration.
How much liquid goes in a 16 mg ARA-290 vial?
There is no single correct volume. More liquid gives fewer micrograms per syringe unit, less gives more. The chart compares several volumes, and any volume on the product label takes priority.
Does this page give an ARA-290 dose?
No. The calculator converts an amount you already have into concentration, mL, and U-100 syringe units. Amount, schedule, and route belong to the product labeling and a qualified professional.